PF-04677490

PF-04677490 is a PDE1 inhibitor (IC50: 21 nM) . PF-04677490 has IC50s of 21 nM, 83 nM, and 118 nM for PDE1B1, PDE1C, and PDE1A, respectively. PF-04677490 efficaciously inhibits cAMP- and cGMP-hydrolytic activity[1].

Product Specifications

CAS Number

[1628342-10-8]

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

CC(CC1=NNC(C)=C1)NC2=C3C=CC(OC)=C(C3=NC=N2)OC

Molecular Formula

C17H21N5O2

Molecular Weight

327.38

References & Citations

[1]Humphrey JM, et al. Discovery of Potent and Selective Periphery-Restricted Quinazoline Inhibitors of the Cyclic Nucleotide Phosphodiesterase PDE1. J Med Chem. 2018 May 24;61 (10) :4635-4640.