WAY-126299A
WAY-126299A is an orally active dual-acting 5-1ipoxygenase inhibitor (IC50: 12.2 μM) and leukotriene D4 antagonist (pKB: 6.4) . WAY-126299A inhibits antigen-induced leukotriene-dependent bronchoconstriction. WAY-126299A can be used for research of asthma[1].
Product Specifications
CAS Number
[169626-43-1]
UNSPSC
12352005
Target
Leukotriene Receptor; Lipoxygenase
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
O=C([C@H](C1=CC=C2C=C(C=CC2=C1)OCC3=NC4=CC=CC=C4S3)C)N(C)O[Na]
Molecular Formula
C22H19N2NaO3S
Molecular Weight
414.45
References & Citations
[1]Howell RE, et al. Pulmonary pharmacology of WAY-126299A: a dual-acting 5-lipoxygenase inhibitor and leukotriene D4 antagonist. Inflamm Res. 1995 Aug;44 Suppl 2:S170-1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-LOX
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