WAY-126299A

WAY-126299A is an orally active dual-acting 5-1ipoxygenase inhibitor (IC50: 12.2 μM) and leukotriene D4 antagonist (pKB: 6.4) . WAY-126299A inhibits antigen-induced leukotriene-dependent bronchoconstriction. WAY-126299A can be used for research of asthma[1].

Product Specifications

CAS Number

[169626-43-1]

UNSPSC

12352005

Target

Leukotriene Receptor; Lipoxygenase

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

O=C([C@H](C1=CC=C2C=C(C=CC2=C1)OCC3=NC4=CC=CC=C4S3)C)N(C)O[Na]

Molecular Formula

C22H19N2NaO3S

Molecular Weight

414.45

References & Citations

[1]Howell RE, et al. Pulmonary pharmacology of WAY-126299A: a dual-acting 5-lipoxygenase inhibitor and leukotriene D4 antagonist. Inflamm Res. 1995 Aug;44 Suppl 2:S170-1.