MS-377

MS-377 is a selective and orally active sigma-1 receptor ligand (Ki=73 nM) with weak affinity for sigma-2 receptor (Ki=6900 nM) and no affinity for any other receptors including dopamine, serotonin, PCP site, glutamate, γ-aminobutylic acid, adenosine, adrenergic receptors, etc. (Ki: >10 μM) . MS-377 indirectly modulates the NMDA receptor ion-channel complex. MS-377 is a antipsychotic agent. MS-377 inhibits PCP-induced behaviors by inhibition of the increase in dopamine and serotonin release in the rat medial prefrontal cortex. MS-377 can be used for research of schizophrenia[1][2].

Product Specifications

CAS Number

[206862-30-8]

UNSPSC

12352005

Target

IGluR; Sigma Receptor

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

O=C1N(C2=CC=C(Cl)C=C2)CC[C@@H]1CN3CCN(CCOC)CC3

Molecular Formula

C18H26ClN3O2

Molecular Weight

351.87

References & Citations

[1]Karasawa, et al. MS-377, a selective sigma receptor ligand, indirectly blocks the action of PCP in the N-methyl-D-aspartate receptor ion-channel complex in primary cultured rat neuronal cells. Life Sci. 2002 Feb 22;70 (14) :1631-42. |[2]Takahashi S, et al. MS-377, a novel selective sigma (1) receptor ligand, reverses phencyclidine-induced release of dopamine and serotonin in rat brain. Eur J Pharmacol. 2001 Sep 21;427 (3) :211-9.