BMS 183920
BMS 183920 is a diacidic and potent angiotensin II receptor antagonist, with a Ki value of 2.9 nM in the rat adrenal cortex binding assay and a KB value of 0.061 nM in the rabbit aorta functional assay. BMS 183920 can be used for research of antihypertensive[1][2].
Product Specifications
UNSPSC
12352005
Target
Angiotensin Receptor
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Smiles
O=C(C1=C(OC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2)C(C5CC5)=NC6=CC=CC=C16)O
Molecular Formula
C26H19N5O3
Molecular Weight
449.46
References & Citations
[1]Obermeier MT, et al. Prodrugs of BMS-183920: metabolism and permeability considerations. J Pharm Sci. 1996 Aug;85 (8) :828-33.|[2]Wexler RR, et al. Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy. J Med Chem. 1996 Feb 2;39 (3) :625-56.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-120134/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
CAS Number
[153072-33-4]
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