BMS 183920

BMS 183920 is a diacidic and potent angiotensin II receptor antagonist, with a Ki value of 2.9 nM in the rat adrenal cortex binding assay and a KB value of 0.061 nM in the rabbit aorta functional assay. BMS 183920 can be used for research of antihypertensive[1][2].

Product Specifications

CAS Number

[153072-33-4]

UNSPSC

12352005

Target

Angiotensin Receptor

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Smiles

O=C(C1=C(OC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2)C(C5CC5)=NC6=CC=CC=C16)O

Molecular Formula

C26H19N5O3

Molecular Weight

449.46

References & Citations

[1]Obermeier MT, et al. Prodrugs of BMS-183920: metabolism and permeability considerations. J Pharm Sci. 1996 Aug;85 (8) :828-33.|[2]Wexler RR, et al. Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy. J Med Chem. 1996 Feb 2;39 (3) :625-56.