FR-182980
FR-182980 is an orally active ACAT1 inhibitor (IC50: 30 nM) . FR-182980 has hypocholesterolemic activity and can be used for research of atherosclerosis[1].
Product Specifications
CAS Number
[179054-51-4]
UNSPSC
12352005
Target
Acyltransferase
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Smiles
O=C(NC1=C(SC)C=C(C)N=C1SC)N(C2CCCCCC2)CC3=CC=C(OC4=CC=C(F)C=C4)C=C3
Molecular Formula
C29H34FN3O2S2
Molecular Weight
539.73
References & Citations
[1]Tanaka A, et al. Inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT) . Part 1: identification and structure-activity relationships of a novel series of substituted N-alkyl-N-biphenylylmethyl-N'-arylureas. Bioorg Med Chem. 1998 Jan;6 (1) :15-30.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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