CFI-401980
CFI-401980 is a selective tyrosine threonine kinase MPS1 inhibitor with a Ki of 0.8 nM. CFI-401980 inhibits the proliferation of HCT116 cell lines. CFI-401980 can be studied in anti-cancer research[1].
Product Specifications
CAS Number
[1610676-27-1]
UNSPSC
12352005
Target
Mps1
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(NC1CC1)C2=CC=C(C3=C4N(N=C3)C(NCC5CCOCC5)=NC(OC6=CC=CC=C6)=N4)C=C2C
Molecular Formula
C28H30N6O3
Molecular Weight
498.58
References & Citations
[1]Laufer, R., et al., (2016) . Discovery of 4- (4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl) benzamides as novel, highly potent and selective, orally bioavailable inhibitors of Tyrosine Threonine Kinase, TTK. Bioorganic & medicinal chemistry letters, 26 (15), 3562-3566.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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