Org-9935
Org-9935 is a selective inhibitor of PDE3 with an IC50 of 50 nM. Org-9935 inhibits maturation of oocyte in naturally selected dominant follicle in rhesus macaques. Org-9935 can augment glucose-induced insulin release in isolated rat islets with an EC50 of 20 μM[1][2][3].
Product Specifications
CAS Number
129425-83-8
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Endocrinology
Smiles
O=C1CC(C)C(C2=CC3=CC(OC)=C(OC)C=C3S2)=NN1
Molecular Formula
C15H16N2O3S
Molecular Weight
304.36
References & Citations
[1]Dent, G., et al., (1991) . Inhibition of eosinophil cyclic nucleotide PDE activity and opsonised zymosan-stimulated respiratory burst by 'type IV'-selective PDE inhibitors. British journal of pharmacology, 103 (2), 1339-1346. |[2]El-Metwally, M., et al., (1997) . The effect of selective phosphodiesterase inhibitors on plasma insulin concentrations and insulin secretion in vitro in the rat. European journal of pharmacology, 324 (2-3), 227-232. |[3]Jensen, J. T., et al., (2008) . The phosphodiesterase 3 inhibitor ORG 9935 inhibits oocyte maturation in the naturally selected dominant follicle in rhesus macaques. Contraception, 77 (4), 303-307.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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