Org-9935

Org-9935 is a selective inhibitor of PDE3 with an IC50 of 50 nM. Org-9935 inhibits maturation of oocyte in naturally selected dominant follicle in rhesus macaques. Org-9935 can augment glucose-induced insulin release in isolated rat islets with an EC50 of 20 μM[1][2][3].

Product Specifications

CAS Number

[129425-83-8]

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Endocrinology

Smiles

O=C1CC(C)C(C2=CC3=CC(OC)=C(OC)C=C3S2)=NN1

Molecular Formula

C15H16N2O3S

Molecular Weight

304.36

References & Citations

[1]Dent, G., et al., (1991) . Inhibition of eosinophil cyclic nucleotide PDE activity and opsonised zymosan-stimulated respiratory burst by 'type IV'-selective PDE inhibitors. British journal of pharmacology, 103 (2), 1339-1346. |[2]El-Metwally, M., et al., (1997) . The effect of selective phosphodiesterase inhibitors on plasma insulin concentrations and insulin secretion in vitro in the rat. European journal of pharmacology, 324 (2-3), 227-232. |[3]Jensen, J. T., et al., (2008) . The phosphodiesterase 3 inhibitor ORG 9935 inhibits oocyte maturation in the naturally selected dominant follicle in rhesus macaques. Contraception, 77 (4), 303-307.