SAS-1121

SAS-1121 is a subtype-selective sigma 2 receptor/PGRMC1 ligand with a Ki of 16.2 nM. SAS-1121 is 574-fold selective for the signma 2 receptor over the sigma 1 receptor. SAS-1121 is a tertiary amine. SAS-1121 can be studied in neurology-related research[1].

Product Specifications

CAS Number

[2095551-67-8]

UNSPSC

12352005

Target

Sigma Receptor

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

O=C(N1CC[C@]2([H])C3=CC=C(N4CCN(CCC(OCC)=O)CC4)C=C3[C@@]1([H])C2)OCC5=CC=CC=C5

Molecular Formula

C28H35N3O4

Molecular Weight

477.60

References & Citations

[1]Sahn, J. J., et al., (2016) . Norbenzomorphan Framework as a Novel Scaffold for Generating Sigma 2 Receptor/PGRMC1 Subtype-Selective Ligands. ChemMedChem, 11 (6), 556-561.