AKI-001

AKI-001 is an prototype pentacyclic inhibitor of aurora kinase with cellular potency of IC50 of less than 100 nM. AKI-001 shows low nanomolar potency against Aurora A and Aurora B enzymes[1].

Product Specifications

CAS Number

[925218-37-7]

UNSPSC

12352005

Target

Aurora Kinase

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

O=C1C(C)(C)C2=CC3=C(C=C2N1CC)C(CCCC4=C(C)NN=C45)=C5N3

Molecular Formula

C21H24N4O

Molecular Weight

348.44

References & Citations

[1]Rawson, T. E., et al., (2008) . A pentacyclic aurora kinase inhibitor (AKI-001) with high in vivo potency and oral bioavailability. Journal of medicinal chemistry, 51 (15), 4465-4475.