AKI-001
AKI-001 is an prototype pentacyclic inhibitor of aurora kinase with cellular potency of IC50 of less than 100 nM. AKI-001 shows low nanomolar potency against Aurora A and Aurora B enzymes[1].
Product Specifications
CAS Number
925218-37-7
UNSPSC
12352005
Target
Aurora Kinase
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C1C(C)(C)C2=CC3=C(C=C2N1CC)C(CCCC4=C(C)NN=C45)=C5N3
Molecular Formula
C21H24N4O
Molecular Weight
348.44
References & Citations
[1]Rawson, T. E., et al., (2008) . A pentacyclic aurora kinase inhibitor (AKI-001) with high in vivo potency and oral bioavailability. Journal of medicinal chemistry, 51 (15), 4465-4475.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS7088351 Inquire
Recombinant Ashbya gossypii Golgi apparatus membrane protein TVP15 (TVP15), partial
Sign In for Pricing
View Details