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Antrafenine (dihydrochloride)

Antrafenine (Stakane) dihydrochloride is a non-narcotic analgesic. Antrafenine dihydrochloride demonstrates central analgesic effects in acetic acid writhing test and mouse hot plate test experiments. Antrafenine dihydrochloride significantly alleviates osteoarthritis pain. Antrafenine dihydrochloride exhibits mild anti-inflammatory activity in a rat toe edema model. Antrafenine dihydrochloride can be used for pain and anti-inflammatory research[1][2].

Product Specifications

CAS Number

55300-30-6

Product Name Alternative

Stakane (dihydrochloride)

UNSPSC

12352005

Target

Others

Related Pathways

Others

Field of Research

Inflammation/Immunology; Neurological Disease

Smiles

O=C(C1=CC=CC=C1NC2=C3C=CC(C(F)(F)F)=CC3=NC=C2)OCCN4CCN(C5=CC=CC(C(F)(F)F)=C5)CC4.Cl.Cl

Molecular Formula

C30H28Cl2F6N4O2

Molecular Weight

661.47

References & Citations

[1]Berry H, et al. Antrafenine, naproxen and placebo in osteoarthritis: a comparative study. Br J Rheumatol. 1983 May;22 (2) :89-94. |[2]Manoury PM, et al. Synthesis and analgesic activities of some (4-substituted phenyl-1-piperazinyl) alkyl 2-aminobenzoates and 2-aminonicotinates. J Med Chem. 1979;22 (5) :554-559.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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