Atiprosine

Atiprosine (AY-28228) is an orally effective selective α1-adrenergic receptor antagonist with a pA2 value of 8.11. Atiprosine exhibits antagonistic activity against α2-adrenergic receptors (α1-adrenergic receptor), 5-HT₂ receptors (5-HT₂ receptor), and H₁ receptors (H₁ receptor) . The pA2 values for these receptors are 6.04, 6.87, and 7.32 respectively. Atiprosine has antihypertensive and hypotensive effects in rats, dogs, and monkeys. It can be used for research on cardiovascular and mental disorders.

Product Specifications

CAS Number

[89303-63-9]

Product Name Alternative

AY-28228

UNSPSC

12352005

Target

5-HT Receptor; Adrenergic Receptor; Histamine Receptor

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Field of Research

Neurological Disease; Cardiovascular Disease

Smiles

CC(C)N1CCN([C@@]2([C@@]1(CCN3C2=C(C4=C3C=CC=C4)C)[H])[H])CC

Molecular Formula

C20H29N3

Molecular Weight

311.46

References & Citations

[1]Oshiro G, et al. Antihypertensive and hypotensive actions of atiprosin (AY-28,228) in rats, dogs, and monkeys. J Cardiovasc Pharmacol. 1987 Sep;10 (3) :341-9.|[2]Grimes D, et al. In vitro isolated tissue studies with atiprosin (AY-28,228) : a new antihypertensive compound. J Cardiovasc Pharmacol. 1987 Sep;10 (3) :249-58.