Trofosfamide-d4
Trofosfamide-d4 is the deuterium labeled Trofosfamide. Trofosfamide is an orally bioavailable oxazaphosphorine derivative with antineoplastic activity[1][2].
Product Specifications
CAS Number
[1189884-36-3]
UNSPSC
12352005
Target
Bacterial; Isotope-Labeled Compounds
Related Pathways
Anti-infection; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Solubility
10 mM in DMSO
Smiles
N(CCCl)(CCCl)P1(=O)N(CCCl)C(C(CO1)([2H])[2H])([2H])[2H]
Molecular Formula
C9H14D4Cl3N2O2P
Molecular Weight
327.61
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Witte HM, et al. Trofosfamide in the treatment of elderly or frail patients with diffuse large B-cell lymphoma. J Cancer Res Clin Oncol. 2019 Jan;145 (1) :129-136.|[3]Görn M, et al. A pilot study of docetaxel and trofosfamide as second-line 'metronomic' chemotherapy in the treatment of metastatic non-small cell lung cancer (NSCLC) . Onkologie. 2008 Apr;31 (4) :185-9.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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