Kaitocephalin
Kaitocephalin (PF1191) is an ionotropic glutamate receptor (NMDAR) antagonist with Ki values of 7.8, 590, and 14000 nM for NMDAR, AMPAR, and KAR, respectively. Kaitocephalin protects neurons by inhibiting excitotoxicity, exhibiting neuroprotective effects. Kaitocephalin can be used in research on neurological diseases such as Alzheimer's disease[1].
Product Specifications
CAS Number
198710-92-8
Product Name Alternative
PF1191
UNSPSC
12352005
Target
IGluR
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
OC([C@H](N)[C@@H]([C@@]1(N[C@@H](C[C@@H](C(O)=O)NC(C2=CC(Cl)=C(O)C(Cl)=C2)=O)CC1)C(O)=O)O)=O
Molecular Formula
C18H21Cl2N3O9
Molecular Weight
494.28
References & Citations
[1]Yasuno Y, et al. Structure-activity relationship study at C9 position of kaitocephalin. Bioorg Med Chem Lett. 2016 Aug 1;26 (15) :3543-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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