Hematein (Standard)

Hematein (Standard) is the analytical standard of Hematein. This product is intended for research and analytical applications. Hematein is a oxidation product of hematoxylin acted as a dye[1]. Hematein is an allosteric casein kinase II inhibitor with an IC50 of 0.74 μM. Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway and increases apoptosis in lung cancer cells[2].

Product Specifications

CAS Number

475-25-2

UNSPSC

12352100

Target

Akt; Apoptosis; Casein Kinase; Reference Standards; Wnt

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Others; PI3K/Akt/mTOR; Stem Cell/Wnt

Field of Research

Cancer

Smiles

O=C1C=C2CC3(C(C4=CC=C(C(O)=C4OC3)O)=C2C=C1O)O

Molecular Formula

C16H12O6

Molecular Weight

300.26

References & Citations

[1]Shirai, K., & Matsuoka, M. (1996) . Structure and properties of hematein derivatives. Dyes and Pigments, 32 (3), 159–169.|[2]Hung MS, et al. Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograftmodel.Int J Oncol. 2013 Nov;43 (5) :1517-22.