Hematein (Standard)
Hematein (Standard) is the analytical standard of Hematein. This product is intended for research and analytical applications. Hematein is a oxidation product of hematoxylin acted as a dye[1]. Hematein is an allosteric casein kinase II inhibitor with an IC50 of 0.74 μM. Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway and increases apoptosis in lung cancer cells[2].
Product Specifications
CAS Number
[475-25-2]
UNSPSC
12352100
Target
Akt; Apoptosis; Casein Kinase; Reference Standards; Wnt
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Others; PI3K/Akt/mTOR; Stem Cell/Wnt
Field of Research
Cancer
Smiles
O=C1C=C2CC3(C(C4=CC=C(C(O)=C4OC3)O)=C2C=C1O)O
Molecular Formula
C16H12O6
Molecular Weight
300.26
References & Citations
[1]Shirai, K., & Matsuoka, M. (1996) . Structure and properties of hematein derivatives. Dyes and Pigments, 32 (3), 159–169.|[2]Hung MS, et al. Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograftmodel.Int J Oncol. 2013 Nov;43 (5) :1517-22.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Curated Selection
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