Tetradifon

Tetradifon is a broad-spectrum organochlorine insecticide and an inhibitor of the mitochondrial oligomycin sensitivity conferring protein (OSCP), which can be used to control a variety of mites. Tetradifon inhibits energy-related activities such as ADP-stimulated respiration, DNP and Mg2+-stimulated ATPase, with an IC50 of 4.5-27 nmoL/mg mitochondrial protein. Tetradifon exerts oligomycin-like activity by inhibiting the oxidative phosphorylation process, inducing oxidative stress and interfering with bone metabolism. Tetradifon is currently mainly used in the research of mitochondrial function regulation, bone remodeling mechanism and nephrotoxicity of environmental pollutants[1][2][3][4][5].

Product Specifications

CAS Number

[116-29-0]

UNSPSC

12352005

Hazard Statement

H302-H410

Target

Insecticide

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Infection

Purity

99.78

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=S(C1=C(C=C(C(Cl)=C1)Cl)Cl)(C2=CC=C(C=C2)Cl)=O

Molecular Formula

C12H6Cl4O2S

Molecular Weight

356.05

Precautions

P264-P270-P273-P330-P391-P501

References & Citations

[1]Desaiah D, et al. Tetradifon (tedion R) : a specific inhibitor of Mg 2+ dependent mitochondrial adenosine triphosphatase activity. Life Sci II. 1972 Apr 8;11 (7) :389-95.|[2]Bustamante E, et al. Tetradifon: an oligomycin-like inhibitor of energy-linked activities of rat liver mitochondria. Biochem Biophys Res Commun. 1973 Mar 17;51 (2) :292-8.|[3]Badraoui R, et al. Effect of subchronic exposure to tetradifon on bone remodelling and metabolism in female rat. C R Biol. 2007 Dec;330 (12) :897-904.|[4]Badraoui R, et al. Nephrotoxic effect of tetradifon in rats: a biochemical and histomorphometric study. Exp Toxicol Pathol. 2012 Sep;64 (6) :645-50.|[5]Fatemeh Ganjeizadeh Rohani, et al. Electropolymerized MIP With MWCNTs on Stir Bar Using Multivariate Optimization for Tetradifon Detection in Date. Pharm Nanotechnol. 2019;7 (5) :404-417.