AT-1459
AT-1459 is a selective and orally active direct Thrombin inhibitor with a Ki value of 4.9 nM. AT-1459 exhibits excellent antithrombotic activity in both rat models of venous and arterial thrombosis. AT-1459 can be used for research on thrombosis-related diseases[1].
Product Specifications
CAS Number
294658-50-7
UNSPSC
12352005
Target
Thrombin
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Smiles
O=C(O)CCCN[C@@H]1C(N(CC(N2[C@H](CCC(N3CC)=CC4=C3C=C(C(N)=N)C=C4)CCC2)=O)CCCC1)=O
Molecular Formula
C29H42N6O4
Molecular Weight
538.68
References & Citations
[1]Cho JH, et al. The antithrombotic efficacy of AT-1459, a novel, direct thrombin inhibitor, in rat models of venous and arterial thrombosis. Thromb Haemost. 2001 Dec;86 (6) :1512-20.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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