Mexiletine-d6

Mexiletine-d6 (KOE-1173-d6) is deuterium labeled Mexiletine. Mexiletine is an orally effective antiarrhythmic agent which has also been found to be effective for myotonia and neuropathic pain. Mexiletine exerts its efficacy through blocking sodium channels (IC50 : 75±8 μM for tonic block, 23.6±2.8 μM for use-dependent block), therefore can be used for cardiovascular and neurological research[1][2][3][4][5].

Product Specifications

CAS Number

[1330267-50-9]

Product Name Alternative

KOE-1173-d6

UNSPSC

12352005

Target

Isotope-Labeled Compounds; Sodium Channel

Related Pathways

Membrane Transporter/Ion Channel; Others

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cardiovascular Disease

Smiles

CC1=C(C(C)=CC=C1)OC([2H])(C([2H])(C([2H])([2H])[2H])N)[2H]

Molecular Formula

C11H11D6NO

Molecular Weight

185.30

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Campbell RW, et al. Mexiletine. N Engl J Med. 1987, 316 (1) :29-34.|[3]De Bellis M, et al. Combined modifications of mexiletine pharmacophores for new lead blockers of Na (v) 1.4 channels. Biophys J. 2013, 104 (2) :344-54.|[4]Nasilli G, et al. Mexiletine reverses oxaliplatin-induced neuropathic pain in rats. J Pharmacol Sci. 2010;112 (4) :473-6.|[5]Egashira N, et al. Mexiletine reverses oxaliplatin-induced neuropathic pain in rats. J Pharmacol Sci. 2010, 112 (4) :473-6.