JTP 2942
JTP 2942 is a thyrotropin-releasing hormone analogue. JTP 2942 can promote the release of Acetylcholine in the hippocampus and frontal cortex of rats. JTP 2942 possesses neuroprotective and cognitive-improving activities. JTP 2942 dose-dependently improves motor and neurological deficits in rat models of chronic focal cerebral ischemia. JTP 2942 can be used for the research of cerebral ischemia, motor neuron diseases, and other related conditions[1][2].
Product Specifications
CAS Number
148152-77-6
UNSPSC
12352005
Target
Thyroid Hormone Receptor
Related Pathways
Vitamin D Related/Nuclear Receptor
Field of Research
Neurological Disease
Smiles
O=C([C@@H]1[C@@H](CC(C1)=O)C)N[C@@H](CC2=CN=CN2)C(N3[C@@H](CCC3)C(N)=O)=O
Molecular Formula
C18H25N5O4
Molecular Weight
375.42
References & Citations
[1]Yonemori F, et al. Effect of JTP-2942, a novel thyrotropin-releasing hormone analog, on motor deficits after chronic focal cerebral ischemia in rats. J Cereb Blood Flow Metab. 2000 Jan;20 (1) :74-81.|[2]Ikeda K, et al. JTP-2942, a novel thyrotropin-releasing hormone analogue, protects against spinal motor neuron degeneration in the wobbler mouse. Neurosci Lett. 1998 Jun 26;250 (1) :9-12.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
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