JTP 2942

JTP 2942 is a thyrotropin-releasing hormone analogue. JTP 2942 can promote the release of Acetylcholine in the hippocampus and frontal cortex of rats. JTP 2942 possesses neuroprotective and cognitive-improving activities. JTP 2942 dose-dependently improves motor and neurological deficits in rat models of chronic focal cerebral ischemia. JTP 2942 can be used for the research of cerebral ischemia, motor neuron diseases, and other related conditions[1][2].

Product Specifications

CAS Number

[148152-77-6]

UNSPSC

12352005

Target

Thyroid Hormone Receptor

Related Pathways

Vitamin D Related/Nuclear Receptor

Field of Research

Neurological Disease

Smiles

O=C([C@@H]1[C@@H](CC(C1)=O)C)N[C@@H](CC2=CN=CN2)C(N3[C@@H](CCC3)C(N)=O)=O

Molecular Formula

C18H25N5O4

Molecular Weight

375.42

References & Citations

[1]Yonemori F, et al. Effect of JTP-2942, a novel thyrotropin-releasing hormone analog, on motor deficits after chronic focal cerebral ischemia in rats. J Cereb Blood Flow Metab. 2000 Jan;20 (1) :74-81.|[2]Ikeda K, et al. JTP-2942, a novel thyrotropin-releasing hormone analogue, protects against spinal motor neuron degeneration in the wobbler mouse. Neurosci Lett. 1998 Jun 26;250 (1) :9-12.