Phenchlobenpyrrone

Phenchlobenpyrrone is a highly selective neuronal calcium antagonist that crosses the blood-brain barrier. Phenchlobenpyrrone mildly inhibits AChE activity. Phenchlobenpyrrone inhibits Aβ aggregation and promotes the clearance of Aβ oligomers. Phenchlobenpyrrone reduces abnormal phosphorylation of Tau protein. Phenchlobenpyrrone may be used in research on Alzheimer's disease[1].

Product Specifications

CAS Number

[215036-81-0]

UNSPSC

12352005

Target

Amyloid-β; Calcium Channel; Cholinesterase (ChE) ; Tau Protein

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

O=C1N[C@@H]([C@H](C1)C2=CC=CC=C2)CC3=CC=CC=C3Cl

Molecular Formula

C17H16ClNO

Molecular Weight

285.77

References & Citations

[1]Yajing MA, et al. Approved drugs and natural products at clinical stages for treating Alzheimer’s disease. Chinese Journal of Natural Medicines. 2024 Aug 1;22 (8) :699-710.