Phenchlobenpyrrone
Phenchlobenpyrrone is a highly selective neuronal calcium antagonist that crosses the blood-brain barrier. Phenchlobenpyrrone mildly inhibits AChE activity. Phenchlobenpyrrone inhibits Aβ aggregation and promotes the clearance of Aβ oligomers. Phenchlobenpyrrone reduces abnormal phosphorylation of Tau protein. Phenchlobenpyrrone may be used in research on Alzheimer's disease[1].
Product Specifications
CAS Number
215036-81-0
UNSPSC
12352005
Target
Amyloid-β; Calcium Channel; Cholinesterase (ChE) ; Tau Protein
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
O=C1N[C@@H]([C@H](C1)C2=CC=CC=C2)CC3=CC=CC=C3Cl
Molecular Formula
C17H16ClNO
Molecular Weight
285.77
References & Citations
[1]Yajing MA, et al. Approved drugs and natural products at clinical stages for treating Alzheimer’s disease. Chinese Journal of Natural Medicines. 2024 Aug 1;22 (8) :699-710.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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