Florantyrone

Florantyrone (Zanchol) is a bile-promoting agent. Florantyrone increases the volume of bile rather than the content of bile acids. Zanchol can stimulate the synthesis of cholesterol in the liver, significantly raising the plasma cholesterol level, increasing the weight of the liver, but has no significant effect on the synthesis of cholesterol in the intestine. Florantyrone can be used in research on biliary motility disorders[1][2][3].

Product Specifications

CAS Number

[519-95-9]

Product Name Alternative

Zanchol

UNSPSC

12352005

Target

Others

Related Pathways

Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Inflammation/Immunology

Smiles

O=C(CCC(C1=CC2=C(C=C1)C3=CC=CC4=CC=CC2=C34)=O)O

Molecular Formula

C20H14O3

Molecular Weight

302.32

References & Citations

[1]MEEROFF M. Acción hidrocolerética de la florantirona [Hydrocholeretic action of florantyrone]. Prensa Med Argent. 1958 Mar 21;45 (12) :1272-6. Spanish.|[2]Raicht RF, et al. Effect of a hydrocholeretic agent (Zanchol) on sterol metabolism in rats. Gastroenterology. 1977 Mar;72 (3) :507-9.|[3]Turley SD, Dietschy JM. Effects of clofibrate, cholestyramine, zanchol, probucol, and AOMA feeding on hepatic and intestinal cholesterol metabolism and on biliary lipid secretion in the rat. J Cardiovasc Pharmacol. 1980;2 (3) :281-97.