Acetoxycycloheximide
Acetoxycycloheximide is an antibiotic with antitumor activity. Acetoxycycloheximide a protein synthesis inhibitor. Acetoxycycloheximide significantly induces activation of procaspase-3 and subsequent apoptosis mediated by the Cytochrome c from mitochondria via activation of JNK pathway. Acetoxycycloheximide triggers the downregulation of cell surface TNF-R1 via the activation of ERK and p38 MAPK, thereby preventing activation of the NF-κB signaling pathway by TNF-α. Acetoxycycloheximide is much more toxic to female rats than to males. Acetoxycycloheximide can be used for inflammatory and immune diseases and cancers research[1][2][3].
Product Specifications
CAS Number
2885-39-4
UNSPSC
12352005
Target
Antibiotic; Apoptosis; Caspase; ERK; JNK; Mitochondrial Metabolism; NF-κB; p38 MAPK; TNF Receptor
Related Pathways
Anti-infection; Apoptosis; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt
Field of Research
Cancer; Inflammation/Immunology
Smiles
O=C(N1)CC(CC1=O)C[C@@H](O)[C@H]2C([C@H](C[C@@](OC(C)=O)(C2)C)C)=O
Molecular Formula
C17H25NO6
Molecular Weight
339.38
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 3; NF-κB
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Lentiviral human RPL10A sgRNA gene knockout kit - Lentiviral human RPL10A sgRNA gene knockout kit (plasmid)