Acetoxycycloheximide

Acetoxycycloheximide is an antibiotic with antitumor activity. Acetoxycycloheximide a protein synthesis inhibitor. Acetoxycycloheximide significantly induces activation of procaspase-3 and subsequent apoptosis mediated by the Cytochrome c from mitochondria via activation of JNK pathway. Acetoxycycloheximide triggers the downregulation of cell surface TNF-R1 via the activation of ERK and p38 MAPK, thereby preventing activation of the NF-κB signaling pathway by TNF-α. Acetoxycycloheximide is much more toxic to female rats than to males. Acetoxycycloheximide can be used for inflammatory and immune diseases and cancers research[1][2][3].

Product Specifications

CAS Number

[2885-39-4]

UNSPSC

12352005

Target

Antibiotic; Apoptosis; Caspase; ERK; JNK; Mitochondrial Metabolism; NF-κB; p38 MAPK; TNF Receptor

Related Pathways

Anti-infection; Apoptosis; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt

Field of Research

Cancer; Inflammation/Immunology

Smiles

O=C(N1)CC(CC1=O)C[C@@H](O)[C@H]2C([C@H](C[C@@](OC(C)=O)(C2)C)C)=O

Molecular Formula

C17H25NO6

Molecular Weight

339.38

References & Citations

[1]PALLOTTA AJ, et al. Toxicology of acetoxycycloheximide as a function of sex and body weight. J Pharmacol Exp Ther. 1962 Jun;136:400-5.|[2]Kadohara K, et al. Acetoxycycloheximide (E-73) rapidly induces apoptosis mediated by the release of cytochrome c via activation of c-Jun N-terminal kinase. Biochem Pharmacol. 2005 Feb 15;69 (4) :551-60.