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MB725

MB725 is an ethylamide analogue of MB710. MB725 increases mRNA levels of a range of p53 target genes, notably PUMA, p21, MDM2, NOXA and BAX. MB725 shows selective anticancer activity against p53-Y220C cancer[1].

Product Specifications

CAS Number

2230058-99-6

UNSPSC

12352005

Target

Bcl-2 Family; MDM-2/p53

Related Pathways

Apoptosis

Field of Research

Cancer

Smiles

O=C(NCC)C=1C(O)=C(I)C(=C2SC(=NC21)N(CC)CC)N3C=CC=C3

Molecular Formula

C18H21IN4O2S

Molecular Weight

484.36

References & Citations

[1]Baud MGJ, et al. Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines. Eur J Med Chem. 2018 May 25;152:101-114.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Bax

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