SAS-0132
SAS-0132 is a selective Sigma 2 receptor (Sig2R) antagonist (Ki: 90 nM) that can cross the blood-brain barrier. SAS-0132 is capable of regulating intracellular Ca2+ levels and modulating PGRMC1-related pathways. SAS-0132 exhibits neuroprotective activity and can improve cognitive impairment in Alzheimer's disease mice. SAS-0132 can be used in the research of neurocognitive disorders such as Alzheimer's disease[1].
Product Specifications
CAS Number
2095551-89-4
UNSPSC
12352005
Target
Calcium Channel; Sigma Receptor
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
O=C(N1CC[C@]2([H])C3=CC=C(N4CCN(C)CC4)C=C3[C@@]1([H])C2)OCC5=CC=CC=C5
Molecular Formula
C24H29N3O2
Molecular Weight
391.51
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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