SAS-0132

SAS-0132 is a selective Sigma 2 receptor (Sig2R) antagonist (Ki: 90 nM) that can cross the blood-brain barrier. SAS-0132 is capable of regulating intracellular Ca2+ levels and modulating PGRMC1-related pathways. SAS-0132 exhibits neuroprotective activity and can improve cognitive impairment in Alzheimer's disease mice. SAS-0132 can be used in the research of neurocognitive disorders such as Alzheimer's disease[1].

Product Specifications

CAS Number

[2095551-89-4]

UNSPSC

12352005

Target

Calcium Channel; Sigma Receptor

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

O=C(N1CC[C@]2([H])C3=CC=C(N4CCN(C)CC4)C=C3[C@@]1([H])C2)OCC5=CC=CC=C5

Molecular Formula

C24H29N3O2

Molecular Weight

391.51

References & Citations

[1]Yi B, et al. Small molecule modulator of sigma 2 receptor is neuroprotective and reduces cognitive deficits and neuroinflammation in experimental models of Alzheimer's disease. J Neurochem. 2017 Feb;140 (4) :561-575.