VU6009453
VU6009453 (compound 15q) is a brain-penetrant M4 mAChR positive allosteric modulator (PAM) with an EC50 of 383 nM. VU6009453 can be used for research on neurological diseases[1].
Product Specifications
CAS Number
[2148929-11-5]
UNSPSC
12352005
Target
MAChR
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(NC1CN(C2=CC(=NC=C2Cl)OC)C1)C=3C=CC=4N=C(C=C(C4C3)C)C
Molecular Formula
C21H21ClN4O2
Molecular Weight
396.88
References & Citations
[1]Long MF, et al. Discovery of a novel 2,4-dimethylquinoline-6-carboxamide M4 positive allosteric modulator (PAM) chemotype via scaffold hopping. Bioorg Med Chem Lett. 2017 Nov 15;27 (22) :4999-5001.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAChR4
Curated Selection
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