CM-414

CM-414 is a brain-penetrant phosphodiesterase 5 (PDE5) and HDAC inhibitor with IC50s of 60 nM, 91 nM, 310 nM, 322 nM and 490 nM for PDE5, HDAC6, HDAC1, HDAC3 and HDAC2, respectively. CM-414 diminishes brain Aβ and tau phosphorylation (pTau) level in Tg2576 mice. CM-414 can be used for the study of Alzheimer's disease (AD) [1][2].

Product Specifications

CAS Number

[2007971-51-7]

UNSPSC

12352005

Target

Amyloid-β; HDAC; Phosphodiesterase (PDE) ; Tau Protein

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

O=C1N=C(NC=2C(=NN(C12)C)CCC)C=3C=C(C=CC3OCC)CC4CC(C(=O)NO)C4

Molecular Formula

C23H29N5O4

Molecular Weight

439.52

References & Citations

[1]Obdulia Rabal, et al. Design, Synthesis, and Biological Evaluation of First-in-Class Dual Acting Histone Deacetylases (HDACs) and Phosphodiesterase 5 (PDE5) Inhibitors for the Treatment of Alzheimer's Disease. J Med Chem. 2016 Oct 13;59 (19) :8967-9004.