AW-814141

AW-814141 is a selective and orally active p38 MAP kinase inhibitor. AW-814141 has an IC50 values of 100 nM and 158 nM for p38-α and β isoforms, respectively. AW-814141 can inhibit the production of TNF-α induced by LPS (HY-D1056) . AW-814141 can inhibit paw edema in rats in a dose-dependent manner. AW-814141 exhibits anti-inflammatory activity and can be used in the research of inflammatory diseases such as rheumatoid arthritis[1].

Product Specifications

CAS Number

[905285-51-0]

UNSPSC

12352005

Target

P38 MAPK

Related Pathways

MAPK/ERK Pathway

Field of Research

Inflammation/Immunology

Smiles

O=C1C(C2=CC=CC=C2C)=CC3=CN=C(NN4CC5C(CCC5)C4)N=C3N1C

Molecular Formula

C22H25N5O

Molecular Weight

375.47

References & Citations

[1]Chopra P, et al. Pharmacological profile of AW-814141, a novel, potent, selective and orally active inhibitor of p38 MAP kinase. Int Immunopharmacol. 2010 Apr;10 (4) :467-73.