AP2238
AP2238 is a dual-function acetylcholinesterase (AChE) inhibitor with Ki values for human AChE (HuAChE) and butyrylcholinesterase (BuChE) of 21.7 and 48.9 μM respectively. AP2238 blocks the pro-fibrotic interaction between the peripheral site of AChE and Aβ, and can inhibit Aβ aggregation. AP2238 can be used for the research of Alzheimer's disease[1].
Product Specifications
CAS Number
[553681-56-4]
UNSPSC
12352005
Target
Amyloid-β; Cholinesterase (ChE)
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
O=C1C(C2=CC=C(CN(C)CC3=CC=CC=C3)C=C2)=CC4=CC(OC)=C(OC)C=C4O1
Molecular Formula
C26H25NO4
Molecular Weight
415.48
References & Citations
[1]Piazzi L, et al. 3- (4-[[Benzyl (methyl) amino]methyl]phenyl) -6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation: a dual function lead for Alzheimer's disease therapy. J Med Chem. 2003 Jun 5;46 (12) :2279-82.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE
Curated Selection
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