SN-28049
SN-28049 is a new DNA-binding topoisomerase II-directed antitumor agent. SN-28049 activates the p53 pathway. SN-28049 exhibits anticancer activity against colorectal cancer[1][2].
Product Specifications
CAS Number
492472-30-7
UNSPSC
12352005
Target
DNA Alkylator/Crosslinker; MDM-2/p53; Topoisomerase
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
O=C(NCCN(C)C)C1=CN(C(C2=CC3=CC=CC(C)=C3N=C12)=O)C
Molecular Formula
C19H22N4O2
Molecular Weight
338.40
References & Citations
[1]Chen YY, et al. Selective cellular uptake and retention of SN 28049, a new DNA-binding topoisomerase II-directed antitumor agent. Cancer Chemother Pharmacol. 2014 Jul;74 (1) :25-35. |[2]Drummond CJ, et al. Action of SN 28049, a new DNA binding topoisomerase II-directed antitumour drug: comparison with doxorubicin and etoposide. Invest New Drugs. 2011 Oct;29 (5) :1102-10.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Topo II
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