SN-28049

SN-28049 is a new DNA-binding topoisomerase II-directed antitumor agent. SN-28049 activates the p53 pathway. SN-28049 exhibits anticancer activity against colorectal cancer[1][2].

Product Specifications

CAS Number

[492472-30-7]

UNSPSC

12352005

Target

DNA Alkylator/Crosslinker; MDM-2/p53; Topoisomerase

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Field of Research

Cancer

Smiles

O=C(NCCN(C)C)C1=CN(C(C2=CC3=CC=CC(C)=C3N=C12)=O)C

Molecular Formula

C19H22N4O2

Molecular Weight

338.40

References & Citations

[1]Chen YY, et al. Selective cellular uptake and retention of SN 28049, a new DNA-binding topoisomerase II-directed antitumor agent. Cancer Chemother Pharmacol. 2014 Jul;74 (1) :25-35. |[2]Drummond CJ, et al. Action of SN 28049, a new DNA binding topoisomerase II-directed antitumour drug: comparison with doxorubicin and etoposide. Invest New Drugs. 2011 Oct;29 (5) :1102-10.