AUY954

AUY954 is an oral active and selective sphingosine-1-phosphate receptor 1 agonist with the EC50 values of 1.2 nM, 0.9 nM >10,000 nM, 1,210 nM, >1,000 nM, and 340 nM for hS1P2, mS1P2, S1P2, S1P3, S1P4, and S1P5 receptors, respectively. AUY954 can be used for study of experimental autoimmune neuritis[1][2].

Product Specifications

CAS Number

[820240-77-5]

UNSPSC

12352100

Target

LPL Receptor

Related Pathways

GPCR/G Protein

Field of Research

Inflammation/Immunology; Neurological Disease

Smiles

O=C(CCNCC1=CC2=C(SC(C3=CC(C(F)(F)F)=C(C4=CC=CC=C4)C=C3)=C2)C=C1)O

Molecular Formula

C25H20F3NO2S

Molecular Weight

455.49

References & Citations

[1]Pan S, et al. A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model. Chem Biol. 2006;13 (11) :1227-1234.|[2]Zhang ZY, et al. AUY954, a selective S1P (1) modulator, prevents experimental autoimmune neuritis. J Neuroimmunol. 2009;216 (1-2) :59-65.