AZ13711265
AZ13711265 is an orally active PAK1 inhibitor with high selectivity. AZ13711265 has IC50 values of 0.58 nM and 0.11 µM for PAK1 and pPAK1, respectively. AZ13711265 has low lipophilicity and low clearance, and can be used as an in vivo probe compound for PAK1. AZ13711265 can be used in the study of cancer[1].
Product Specifications
CAS Number
2016806-55-4
UNSPSC
12352005
Target
PAK
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Field of Research
Cancer
Smiles
OCC1=CC(N(C2=NC(NC3=CC=C(N4[C@](C5)([H])CN(C)[C@]5([H])C4)C(S(=O)(CC)=O)=C3)=NC=C2F)C)=C(C)C=C1C
Molecular Formula
C28H35FN6O3S
Molecular Weight
554.68
References & Citations
[1]McCoull W, et al. Optimization of Highly Kinase Selective Bis-anilino Pyrimidine PAK1 Inhibitors. ACS Med Chem Lett. 2016 Sep 14;7 (12) :1118-1123.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PAK1
Frequently Asked Questions
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