Lotifazole

Lotifazole (F 1686) is a non-steroidal anti-inflammatory agent. Lotifazole exhibits specific inhibition of delayed-type hypersensitivity and does not rely on the prostaglandin synthesis inhibition pathway at low doses. Lotifazole shows significant efficacy in treating paw edema induced by carrageenan in rats, erythema induced by ultraviolet radiation in guinea pigs, and pleurisy at high doses. Lotifazole can be used for the study of T-cell-mediated diseases[1].

Product Specifications

CAS Number

[71119-10-3]

Product Name Alternative

F 1686

UNSPSC

12352005

Target

Others

Related Pathways

Others

Field of Research

Inflammation/Immunology

Smiles

O=C(NC1=NC(C2=CC=CC=C2)=CS1)OCC(Cl)(Cl)Cl

Molecular Formula

C12H9Cl3N2O2S

Molecular Weight

351.64

References & Citations

[1]Tarayre JP, et al. Lotifazole (F 1686), a non-steroidal anti-inflammatory agent with an unusual pharmacological spectrum. Agents Actions. 1984 Jan;14 (1) :93-101.