DC-S238

DC-S238 is an orally active and highly selective histone methyltransferase SET7 (SETD7) inhibitor (IC50=4.88 μM) . DC-S238 is promising for research of cancer, diabetes and inflammatory diseases[1].

Product Specifications

CAS Number

[832109-48-5]

UNSPSC

12352005

Target

Histone Methyltransferase

Related Pathways

Epigenetics

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology

Smiles

O=C(OC)C1=C(SC(C(NC2=CC=CC([N+]([O-])=O)=C2)=O)=C1C)N

Molecular Formula

C14H13N3O5S

Molecular Weight

335.34

References & Citations

[1]Meng F, et al. Discovery and Optimization of Novel, Selective Histone Methyltransferase SET7 Inhibitors by Pharmacophore- and Docking-Based Virtual Screening. J Med Chem. 2015 Oct 22;58 (20) :8166-81.