CP-664511

CP-664511 is an orally active and potent α4β1 integrin antagonist with anti-inflammatory effects (IC50=0.52 nM) . CP-664511 inhibits the interaction between α4β1 and vascular cell adhesion molecule-1 (VCAM-1), significantly reducing eosinophil infiltration into lung tissue. CP-664511 is promising for research of asthma and allergic airway diseases[1].

Product Specifications

CAS Number

[379692-00-9]

UNSPSC

12352005

Target

Integrin

Related Pathways

Cytoskeleton

Field of Research

Inflammation/Immunology

Smiles

O=C(O)CCC1=CC([C@@H](NC(CC2=CC=C(NC(NC3=CC=CC=C3C)=O)C(OC)=C2)=O)CC(C)C)=NO1

Molecular Formula

C28H34N4O6

Molecular Weight

522.59

References & Citations

[1]Kudlacz E, et al. Pulmonary eosinophilia in a murine model of allergic inflammation is attenuated by small molecule alpha4beta1 antagonists. J Pharmacol Exp Ther. 2002 May;301 (2) :747-52.