CP-664511
CP-664511 is an orally active and potent α4β1 integrin antagonist with anti-inflammatory effects (IC50=0.52 nM) . CP-664511 inhibits the interaction between α4β1 and vascular cell adhesion molecule-1 (VCAM-1), significantly reducing eosinophil infiltration into lung tissue. CP-664511 is promising for research of asthma and allergic airway diseases[1].
Product Specifications
CAS Number
379692-00-9
UNSPSC
12352005
Target
Integrin
Related Pathways
Cytoskeleton
Field of Research
Inflammation/Immunology
Smiles
O=C(O)CCC1=CC([C@@H](NC(CC2=CC=C(NC(NC3=CC=CC=C3C)=O)C(OC)=C2)=O)CC(C)C)=NO1
Molecular Formula
C28H34N4O6
Molecular Weight
522.59
References & Citations
[1]Kudlacz E, et al. Pulmonary eosinophilia in a murine model of allergic inflammation is attenuated by small molecule alpha4beta1 antagonists. J Pharmacol Exp Ther. 2002 May;301 (2) :747-52.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
α4β1
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