PX-316
PX-316 is an Akt inhibitor. PX-316 can phosphorylate Akt, but does not inhibit the phosphorylation of PDK1 or PKC. PX-316 uniquely increases the expression of a group of mitochondrial-related genes. PX-316 can be used for the study of colon cancer and breast cancer[1].
Product Specifications
CAS Number
[253440-95-8]
UNSPSC
12352211
Target
Akt
Related Pathways
PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
CCCCCCCCCCCCCCCCCCOC[C@@H](OC)COP(O[C@H]1[C@@H]([C@H]([C@@H](C[C@H]1O)O)O)O)(O)=O
Molecular Formula
C28H57O10P
Molecular Weight
584.72
References & Citations
[1]Meuillet EJ, et al. In vivo molecular pharmacology and antitumor activity of the targeted Akt inhibitor PX-316. Oncol Res. 2004;14 (10) :513-27.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Akt
Curated Selection
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