J-30

J-30 is an orally active and potent tubulin inhibitor (IC50=15-20 nM) . J-30 disrupts microtubule polymerization and induces G2/M phase arrest. J-30 is promising for research of solid tumors (e.g., gastric, oral) [1].

Product Specifications

CAS Number

[916484-16-7]

UNSPSC

12352005

Target

Microtubule/Tubulin

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Field of Research

Cancer

Smiles

O=C(C1=CC=NC=C1)NC2=CC=CC3=C2N(CC3)S(=O)(C4=CC=C(C=C4)OC)=O

Molecular Formula

C21H19N3O4S

Molecular Weight

409.46

References & Citations

[1]Liou JP, et al. A novel oral indoline-sulfonamide agent, N-[1- (4-methoxybenzenesulfonyl) -2,3-dihydro-1H-indol-7-yl]-isonicotinamide (J30), exhibits potent activity against human cancer cells in vitro and in vivo through the disruption of microtubule. J Pharmacol Exp Ther. 2007 Oct;323 (1) :398-405.