J-30
J-30 is an orally active and potent tubulin inhibitor (IC50=15-20 nM) . J-30 disrupts microtubule polymerization and induces G2/M phase arrest. J-30 is promising for research of solid tumors (e.g., gastric, oral) [1].
Product Specifications
CAS Number
[916484-16-7]
UNSPSC
12352005
Target
Microtubule/Tubulin
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Field of Research
Cancer
Smiles
O=C(C1=CC=NC=C1)NC2=CC=CC3=C2N(CC3)S(=O)(C4=CC=C(C=C4)OC)=O
Molecular Formula
C21H19N3O4S
Molecular Weight
409.46
References & Citations
[1]Liou JP, et al. A novel oral indoline-sulfonamide agent, N-[1- (4-methoxybenzenesulfonyl) -2,3-dihydro-1H-indol-7-yl]-isonicotinamide (J30), exhibits potent activity against human cancer cells in vitro and in vivo through the disruption of microtubule. J Pharmacol Exp Ther. 2007 Oct;323 (1) :398-405.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-119118/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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