PF-03246799 (monohydrochloride)
PF-03246799 monohydrochloride is a potent and selective 5-HT2C receptor agonist with an EC50 of 190 nM and a Ki of 160 nM. PF-03246799 monohydrochloride shows selectivity for 5-HT2C over 5-HT2A and 5-HT2B receptors. PF-03246799 monohydrochloride has the potential for stress urinary incontinence (SUI) research[1].
Product Specifications
CAS Number
[1613666-08-2]
UNSPSC
12352005
Target
5-HT Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
C12=NC(CC3=CC=CC=C3)=NC=C1CCNCC2.Cl
Molecular Formula
C15H18ClN3
Molecular Weight
275.78
References & Citations
[1]Andrews MD, et al. Pyrimido[4,5-d]azepines as potent and selective 5-HT2C receptor agonists: design, synthesis, and evaluation of PF-3246799 as a treatment for urinary incontinence. Bioorg Med Chem Lett. 2011 May 1;21 (9) :2715-20.
Shipping Conditions
Room temperature
Scientific Category
Reference compound
Clinical Information
No Development Reported
Isoform
5-HT2 Receptor
Curated Selection
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