ACT-281959

ACT-281959 is an orally active prodrug of Selatogrel (HY-109122), a P2Y12 receptor antagonist. ACT-281959 can inhibit platelet aggregation and can be used for the research of cardiovascular disease[1].

Product Specifications

CAS Number

[1159501-31-1]

UNSPSC

12352005

Target

P2Y Receptor

Related Pathways

GPCR/G Protein

Field of Research

Cardiovascular Disease

Smiles

O=C(N1CCN(C([C@@H](NC(C2=NC(C3=CC=CC=C3)=NC(N4C[C@@H](OC)CC4)=C2)=O)CP(OCOC(OC(C)C)=O)(OCOC(OC(C)C)=O)=O)=O)CC1)OCCCC

Molecular Formula

C38H55N6O14P

Molecular Weight

850.85

References & Citations

[1]Caroff E, et al. 4- ((R) -2-{[6- ((S) -3-Methoxypyrrolidin-1-yl) -2-phenylpyrimidine-4-carbonyl]amino}-3-phosphonopropionyl) piperazine-1-carboxylic Acid Butyl Ester (ACT-246475) and Its Prodrug (ACT-281959), a Novel P2Y12 Receptor Antagonist with a Wider Therapeutic Window in the Rat Than Clopidogrel. J Med Chem. 2015 Dec 10;58 (23) :9133-53.