GSK2181236A
GSK2181236A is a NO-insensitive soluble guanylate cyclase (sGC) activator. GSK2181236A can dilate blood vessels, decrease mean arterial pressure and attenuate the development of cardiac hypertrophy. GSK2181236A can be used for the research of cardiovascular disease, such as hypertension[1].
Product Specifications
CAS Number
[1160426-89-0]
UNSPSC
12352005
Target
Guanylate Cyclase
Related Pathways
GPCR/G Protein
Field of Research
Cardiovascular Disease
Smiles
O=C(C1=C(C(F)(F)F)N(C2=NC(C3=CC=CC=C3OCC4=CC=C(C5=CC=C(OC(F)(F)F)C=C5)C=C4C)=CC=C2)N=C1)O
Molecular Formula
C31H21F6N3O4
Molecular Weight
613.51
References & Citations
[1]Costell MH, et al. Comparison of soluble guanylate cyclase stimulators and activators in models of cardiovascular disease associated with oxidative stress. Front Pharmacol. 2012 Jul 5;3:128
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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