A-800141
A-800141 is an orally active and selective MetAP2 inhibitor with an IC50 of 12 nM. A-800141 has weak inhibitory activity for MetAP1 (IC50 : 36 μM) . GAPDH can be used as a biomarker to monitor the MetAP2 inhibition of A-800141. A-800141 has antiangiogenic and anticancer activity in a variety of xenograft tumor models[1].
Product Specifications
CAS Number
[681245-85-2]
UNSPSC
12352005
Target
MetAP
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer; Cardiovascular Disease
Smiles
O=C(C1=C2CCCCC2=CC=C1NS(=O)(C3=CC=CC=C3/C=C\CN(CC)CC)=O)O
Molecular Formula
C24H30N2O4S
Molecular Weight
442.57
References & Citations
[1]Wang J, et al. Correlation of tumor growth suppression and methionine aminopetidase-2 activity blockade using an orally active inhibitor. Proc Natl Acad Sci U S A. 2008 Feb 12;105 (6) :1838-43.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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