CGP-74514 (hydrochloride)
CGP-74514 hydrochloride is a highly selective cyclin-dependent kinase 1 (CDK1) inhibitor (IC50: 25 nM) . CGP-74514 hydrochloride inhibits CDK1/cyclin B complex activity, arrests the cell cycle at G2/M phase and induces tumor cell apoptosis. CGP-74514 hydrochloride is promising for research of bladder cancer[1][2].
Product Specifications
CAS Number
481724-82-7
Product Name Alternative
CGP-74514A
UNSPSC
12352005
Target
Apoptosis; CDK
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
CCN1C2=NC(N[C@@H]3[C@@H](CCCC3)N)=NC(NC4=CC(Cl)=CC=C4)=C2N=C1.Cl
Molecular Formula
C19H25Cl2N7
Molecular Weight
422.35
References & Citations
[1]Furet P, et al. Structure-based design of potent CDK1 inhibitors derived from olomoucine. J Comput Aided Mol Des. 2000 Jul;14 (5) :403-9. |[2]Imbach P, et al. 2,6,9-trisubstituted purines: optimization towards highly potent and selective CDK1 inhibitors. Bioorg Med Chem Lett. 1999 Jan 4;9 (1) :91-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK1
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