LAF389
LAF389, a benaamide B analogue, is a methionine aminopeptidases (MetAps) inhibitor with an IC50 of 800 nM for MetAp2. LAF389 has both antiproliferative and antiangiogenetic properties and can inhibit tumor cells growth. LAF389 can be used for the research of cancer[1][2].
Product Specifications
CAS Number
270902-51-7
UNSPSC
12352005
Target
MetAP
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CC(C)(C)/C=C/[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC)C(N[C@H]1CC[C@H](CNC1=O)OC(C2CCCCC2)=O)=O
Molecular Formula
C25H42N2O8
Molecular Weight
498.61
References & Citations
[1]Towbin H, et al. Proteomics-based target identification: bengamides as a new class of methionine aminopeptidase inhibitors. J Biol Chem. 2003 Dec 26;278 (52) :52964-71.|[2]Dumez H, et al. A phase I and pharmacokinetic study of LAF389 administered to patients with advanced cancer. Anticancer Drugs. 2007 Feb;18 (2) :219-25.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MetAP2
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