Piperaquine-d6 (tetraphosphate)
Piperaquine-d6 (tetraphosphate) is the deuterium labeled Piperaquine tetraphosphate. Piperaquine tetraphosphate is a bisquinoline antimalarial agent. Piperaquine phosphate can be used in antimalarial research in combination with Artemisinin[1][2].
Product Specifications
UNSPSC
12352005
Target
Isotope-Labeled Compounds; Parasite
Related Pathways
Anti-infection; Others
Applications
COVID-19-immunoregulation
Field of Research
Infection
Solubility
10 mM in DMSO
Smiles
ClC1=CC2=C(C=C1)C(N3CCN(CC3)C([2H])([2H])C([2H])([2H])C([2H])([2H])N4CCN(C5=CC=NC6=C5C=CC(Cl)=C6)CC4)=CC=N2.O=P(O)(O)O.O=P(O)(O)O.O=P(O)(O)O.O=P(O)(O)O
Molecular Formula
C29H38D6Cl2N6O16P4
Molecular Weight
933.53
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Moore BR, et, al. Pharmacokinetics and pharmacodynamics of piperaquine in a murine malaria model. Antimicrob Agents Chemother. 2008 Jan; 52 (1) : 306-11.|[3]Davis TME, et, al. Piperaquine: a resurgent antimalarial drug. Drugs. 2005; 65 (1) : 75-87.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
Plasmodium
Available Sizes
Curated Selection
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