Amonafide (L-malate)
Amonafide L-malate is a topoisomerase II inhibitor and DNA intercalator that induces Apoptotic signaling by blocking the binding of Topo II to DNA[1][2][3].
Product Specifications
CAS Number
[618863-54-0]
Product Name Alternative
AS-1413 (L-malate)
UNSPSC
12352005
Target
Apoptosis; DNA Alkylator/Crosslinker; Topoisomerase
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
OC(C[C@H](O)C(O)=O)=O.O=C1C2=CC(N)=CC3=C2C(C(N1CCN(C)C)=O)=CC=C3
Molecular Formula
C20H23N3O7
Molecular Weight
417.41
References & Citations
[1]Allen SL, et al. Amonafide: a potential role in treating acute myeloid leukemia. Expert Opin Investig Drugs. 2011 Jul;20 (7) :995-1003.|[2]Andersson BS, et al. In vitro toxicity and DNA cleaving capacity of benzisoquinolinedione (nafidimide; NSC 308847) in human leukemia. Cancer Res. 1987 Feb 15;47 (4) :1040-4. |[3]Ajani JA, et al. In vitro activity of amonafide against primary human tumors compared with the activity of standard agents. Invest New Drugs. 1988 Jun;6 (2) :79-85.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-118823/
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
Topo II
Curated Selection
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